Northbound Interstate 71 will close through Fort Washington Way and the Lytle Tunnel this weekend.
The closures will run 10 p.m. Friday until 8 a.m. Saturday and the same times Saturday night into Sunday morning.
Detour around by taking northbound I-75 to eastbound Norwood Lateral to I-71 in either direction.
The Ohio Department of Transportation said it must close the highway to do maintenance and inspection work on I-71 and the tunnel.
Arrow signs and boards will be posted to alert motorists.
Drivers are asked to reduce speed as they approach.
Eastbound Fort Washington Way to US-50/Columbia Parkway will remain open.